Cannabinoids 2007;2(1):1-2 (21 January 2007)

Comment

In humans, ajulemic acid has a more favorable side-effect profile than THC for the treatment of chronic neuropathic pain

Sumner H. Burstein

Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA, sumner.burstein@umassmed.edu

This is a comment on a report by Vann et al. (2006) on the pharmacological effects of ajulemic acid compared to CB1 receptor agonists. Their data, which were obtained using animal models, suggested an unfavorable therapeutic index as an analgesic. However, the available clinical data do not support such conclusions and indicate a deficiency in some of their models.

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